Publication Type: Journal article
Year: 2022
Author(s): Chad Lance Hemady, Lydia Gabriela Speyer, Aja Louise Murray, Ruth Harriet Brown, Franziska Meinck, Deborah Fry, Huyen Do, Siham Sikander, Bernadette Madrid, Asvini Fernando, Susan Walker, Michael Dunne, Sarah Foley, Claire Hughes, Joseph Osafo, Adriana Baban, Diana Taut, Catherine L. Ward, Vo Van Thang, Pasco Fearon, Mark Tomlinson, Sara Valdebenito & Manuel Eisner 
Unit: SaVI
Journal: BMC Pregnancy and Childbirth

Abstract: "Background: This paper enumerates and characterizes latent classes of adverse childhood experiences and investigates how they relate to prenatal substance use (i.e., smoking, alcohol, and other drugs) and poor infant outcomes (i.e., infant prematurity and low birthweight) across eight low- and middle-income countries (LMICs). Methods: A total of 1189 mother-infant dyads from the Evidence for Better Lives Study cohort were recruited. Latent class analysis using the Bolck, Croon, and Hagenaars (BCH) 3-step method with auxiliary multilevel logistic regressions was performed. Results: Three high-risk classes and one low-risk class emerged: (1) highly maltreated (7%, n = 89), (2) emotionally and physically abused with intra-familial violence exposure (13%, n = 152), (3), emotionally abused (40%, n = 474), and (4) low household dysfunction and abuse (40%, n = 474). Pairwise comparisons between classes indicate higher probabilities of prenatal drug use in the highly maltreated and emotionally abused classes compared with the low household dysfunction and abuse class. Additionally, the emotionally and physically abused with intra-familial violence exposure class had higher probability of low birthweight than the three remaining classes. Conclusion: Our results highlight the multifaceted nature of ACEs and underline the potential importance of exposure to childhood adversities on behaviors and outcomes in the perinatal period. This can inform the design of antenatal support to better address these challenges."

Citation:   Hemady, C.L., Speyer, L.G., Murray, A.L., Brown, R.H., Meinck, F., Fry, D., Do, H., Sikander, S., Madrid, B., Fernando, A., Walker, S., Dunne, M., Foley, S.,Hughes, C., Osafo, J., Baban, A., Taut, D., Ward, C.L., Vo Van, T., Fearon, P., Tomlinson, M., Valdebenito, S., Eisner, M. (2022). Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: A Latent Class Analysis. BMC Pregnancy and Childbirth