The Centre for Creative Writing offers the premier creative writing programme on the African continent, which enables aspiring writers and poets to refine their work under the guidance of some of the best writers in South Africa.

Eminent writers like Professor Andre Brink, Professor Etienne van Heerden, Mike Nicol, Breyten Breytenbach, Damon Galgut and Christopher Hope have all taught in the programme, as well as up and coming writers like Henrietta Rose-Innes, Roy Robins, Rayda Jacobs and Andre Wiesner. Every year, UCT is blessed with writers who visit from overseas; these have included Zakes Mda, Zoe Wicomb, Willy Kgotsitsile, Jenefer Shute and Justin Cartwright.

Students at the centre, located in La Grotta on middle campus, undertake academic modules and craft workshops. Students critically evaluate each other's work, as well as doing a survey in either fiction or poetry. A programme of monthly readings by the MA students forms an essential part of the creative writing centre's annual activities. The literary magazine, New Contrast, while an independent organ, is closely affiliated with the UCT.